GBA1 and Parkinson disease: PD patients with the A53T α-syn mutation experience worse autonomic and cognitive deterioration,188 while apolipoprotein E (APOE4) and glucosidase beta acid 1 (GBA1) PD patients have accelerated cognitive189–193 and motor deterioration,194 although this may be constrained to specific mutations/polymorphisms.195–197 Polygenic risk scores for predicting the rate of progression appear promising but need replication.198,199