For example, [18F]FDG can(1) be reduced with NaBH4 to produce the Enterobacteriaceae-targeted PET radiotracer 2-deoxy-[18F]-fluoro-d-sorbitol ([18F]FDS),7,8 (2) be derivatizedwith amines and other substituents to yield analyte-sensitive “caged”prodrugs,9,10 and (3) be employed as a prosthetic groupto label drugs and peptide structures.11,12 These approachescan be used to easily transform [18F]FDG into tracers targetingbacterial metabolism, the tumoral microenvironment, or specific oncologictargets, for example, the prostate-specific membrane antigen (PSMA)found in prostate cancer. Here, FOLH1 is linked to prostate carcinoma.