Stratified by gene group, 46 (0.8%) had a BRCA1/2 PLPV identified through comprehensive BRCA1/2 analysis; 60 (1.0%) had a PLPV in any of seven high-risk breast cancer genes; and 136 (2.3%) had a PLPV in any of 19 genes associated with breast or ovarian cancer (Table 3). This evidence concerns the gene BRCA1 and ovarian cancer.