When stratified by gene group, 2,721 (3.5%) individuals had BRCA1/2 PLPV on comprehensive sequencing of BRCA1/2; 3,489 (4.5%) individuals had a PLPV in one of the seven high-risk breast cancer genes; and 5,944 (7.7%) had a PLPV in one of the 19 breast or ovarian cancer genes (Table 3). This evidence concerns the gene BRCA1 and breast cancer.