TMEM97 and Niemann-Pick disease, type C1: TMEM97 is thought to play a role incholesterol homeostasis and function as a modulator of the steroltransporter Niemann–Pick disease type C1.16 It is thought that S2R is trafficked through multiple subcellularstructures including the ER, lysosomes, and mitochondria, and modulationof the S2R can result in numerous tissue and cell-specific cell andmolecular outcomes such as the release of intracellular Ca2+, dopaminergic transmission, and neurodegeneration as well as thepathogenesis of cancer and neurological disorders.17