In CDAA-HF-T(−)-T versus CDAA-HF-T(−)-N, the upregulated signaling pathways included those related to exogenous chemometabolism, such as the constitutive androstane receptor and aryl hydrocarbon receptor, IL-8, hypoxia-inducible factor-1α, and estrogen biosynthesis. The gene discussed is CXCL8; the disease is hydrops fetalis.