Other identified common up-regulated hub genes such as AKAP12 [85,86], WFDC2 [87,88], CALD1 [89,90], and VSNL1 [91,92] are related to drug resistance in various cancers although their involvement in oxaliplatin resistance in CRC was not identified and can be reported as protentional biomarkers which merits further exploration. The gene discussed is WFDC2; the disease is cancer.