AKAP12 and cancer: Other identified common up-regulated hub genes such as AKAP12 [85,86], WFDC2 [87,88], CALD1 [89,90], and VSNL1 [91,92] are related to drug resistance in various cancers although their involvement in oxaliplatin resistance in CRC was not identified and can be reported as protentional biomarkers which merits further exploration.