The mRNA expression level of FXYD3, LGALS4, USH1C, ECI2, TGM2, and HMGA2 genes which are involved in EMT, drug resistance, and cancer progression were measured in HCT116/OX-R4.3 and HCT116/OX-R10 cells by qRT-PCR. This evidence concerns the gene HMGA2 and cancer.