Moreover, western blotting indicated that UBE2C siRNAs can inhibit proliferation, inhibit damage repair of DNA, and induced apoptosis in ACC cells, characterized by the increased expression of cleased-Caspase-7 as well as the decreased expression of cleased-PARP-1, C-myc, cyclin D1 (Fig 8F). The gene discussed is CASP7; the disease is adrenal cortex carcinoma.