At first, a previously published geneset [17] was analyzed for understanding the correlation between UBE2C expression and the activation of several signaling pathway in ACC implemented by ACLBI Web-based Tools, and the results showed that UBE2C expression was positively correlated with the activation of cell cycle, proliferation, and metastasis (Fig 5). The gene discussed is UBE2C; the disease is adrenal cortex carcinoma.