MMP2 and adrenal cortex carcinoma: For tumor invasion requiring both degradation of ECM components and cell migration, we performed western blotting and found that UBE2C knockdown indeed inhibited EMT of adrenocortical carcinoma cells, manifested as the decreased expression of N-cad, Vimentin, snail, MMP2 and increased expression of E-cadherin (Fig 8E).