On the one hand, based on the description of hallmarks of cancer proposed by Professor Douglas Hanahan [30], it has been confirmed that UBE2C can promote tumor growth [31], angiogenesis [32], tumor metastasis [33, 34], anchorage-independent growth [35], stemness [36], resist apoptosis [37, 38], induce immunosuppressive microenvironment [39], and enhance glycolytic activity [40, 41]. Here, UBE2C is linked to neoplasm.