TP63-related disorders are a spectrum of six autosomal dominant syndromes including Ankyloblepharon–ectodermal defects–cleft lip/palate (AEC) syndrome; Acro-dermo-ungual–lacrimal–tooth (ADULT) syndrome; Ectrodactyly, ectodermal dysplasia, cleft lip/palate syndrome 3 (EEC3); Limb–mammary syndrome; Split-hand/foot malformation type 4 (SHFM4) and Isolated cleft lip/cleft palate (orofacial cleft 8) [33–35]. Here, TP63 is linked to split hand-foot malformation 4.