The greatest biological significance in bladder cancer is the change in protein N-glycans, which include β1-6 branching of N-glycans due to overexpression of the enzyme GlcNAcT-V (GnT-V) and the addition of bisecting GlcNAc branches by GlcNAcT-III (GnT-III) glycosyltransferases (Takahashi et al. 2006). The gene discussed is MGAT5; the disease is urinary bladder carcinoma.