Moreover, gene set enrichment analysis showed that pro-inflammatory related T cell receptor signaling pathway (FDR = 0.016; Figure 6D), B cell receptor signaling pathway (FDR = 0.014; Figure 6E), and chemokine signaling pathway (FDR = 0.007; Figure 6F) were all noticed in melanoma patients with SETBP1 mutations (Supplementary Figure 6). The gene discussed is SETBP1; the disease is melanoma.