In GEMMs of intrahepatic cholangiocarcinoma (ICC) [86], Haining Liu and colleagues demonstrated that co-inhibition of both CXCR2 and METTL1, a protein directly involved in the expression of the soluble chemo attractants CXCL5/CXCL8, in combination with anti-PD-1, achieved a complete response, with a survival rate of 100% during 60 days of tracking [87]. This evidence concerns the gene PDCD1 and intrahepatic cholangiocarcinoma.