In studies of renal diseases, sirtuin 1 (SIRT1) can inhibit the expression of various inflammatory signaling pathways to regulate renal interstitial fibrosis.12 It has been found that overexpression of SIRT1 can inhibit inflammatory reactions by inhibiting the NLRP3/caspase-1-mediated canonical pyroptosis pathway and protect cells and tissues.13 14 LPS can promote inflammation by inhibiting the expression of SIRT1 in cells, and agonists of SIRT1 can reduce the cell damage and inflammatory response induced by LPS. Here, SIRT1 is linked to kidney disorder.