Even though the obese group had presented an increase in their systemic IL-6 concentration, which chronically can increase the vulnerability to unhealthy clinical outcomes related to inflammaging (13, 15), our data corroborate the expectation that among older women with obesity, the body fat loss should be desirable (8, 9, 25) and also that better control of inflammatory status can positively impact on physical activity performance. Here, IL6 is linked to obesity due to melanocortin 4 receptor deficiency.