The only exceptions are also the presence of CDKN2A/B homozygous deletion for IDHm astrocytoma, and of TERT promoter mutation, EGFR gene amplification, and chromosome 7 gain/chromosome 10 loss for IDH wild-type diffuse astrocytomas, which classify them as grade IV, which were missing in our study. This evidence concerns the gene IDH1 and astrocytoma (excluding glioblastoma).