NFE2L2 and early-onset autosomal dominant Alzheimer disease: For example, while Nrf2 activation was detected in some studies on Alzheimer's disease (AD) (Raina et al., 1999[221]; SantaCruz et al., 2004[230]; Schipper et al., 1995[233]; Tanji et al., 2013[263]; Wang et al., 2000[284]), Nrf2 suppression was shown in others (Johnson and Johnson, 2015[120]; Ramsey et al., 2007[224]).