The top 2 upregulated cancer hallmarks were TGF-β signaling (t = −13.548, P < 0.001) and mTORC1 signaling (t = −11.702, P < 0.001), whereas the most downregulated cancer hallmark was fatty acid metabolism (t = 17.671, P < 0.001). This evidence concerns the gene TGFB1 and cancer.