In the subgroup analysis, female, patients with lung-only metastasis, hand-foot skin syndrome (HFS), and thyroglobulin response ≥ 60% observed longer PFS (<i>p</i> = 0.038, 0.045, 0.035, and 0.000, respectively), while patients with bone metastasis had lower PFS (<i>p</i> = 0.035). The gene discussed is TG; the disease is Hand-foot syndrome.