For example, lipotoxic hepatocytes exosome transplantation aggravated the degree of PTEN-induced expression of putative protein kinase 1 (PINK1) mediated mitophagy suppression, steatohepatitis, lipidosis, and fibrosis in the livers of NAFLD mice with cirrhosis (108). The gene discussed is PTEN; the disease is metabolic dysfunction-associated steatotic liver disease.