To examine the permissiveness of NDUFA4−/− and WT hiPSCs to ZIKV infection in vivo, hiPSCs were transplanted subcutaneously into immune-deficient SCID-beige mice, and the mice were inoculated with ZIKVU by intraperitoneal injection two weeks post-transplantation (Figure 3F). The gene discussed is COXFA4; the disease is Zika virus infectious disease.