As reported, the transmembrane protein Ccdc25 is a NET-DNA receptor on cancer cells that senses extracellular DNA and subsequently activates the ILK–β-parvin pathway to enhance cell motility,40 so we inferred that NETosis recruited immune cells via Ccdc25. To validate this hypothesis, Ccdc25 was expressed in immune cells in the GCM group, especially macrophage Cluster 1/2 and Th17 cells, and IHC staining was conducted to suggest that the expression of Ccdc25 was higher in the GCM group (Figure 4H). The gene discussed is CCDC25; the disease is cancer.