INS and obesity due to melanocortin 4 receptor deficiency: The pro-adipogenic pathway of phytoestrogens in the modulation of obesity is related to a reduction of insulin (INS) resistance, activation of estrogen receptors (ERs), inhibition of reactive oxygen species, activation of antioxidants, and decreases of lipoprotein lipase, fatty acid synthase, and cyclic adenosine monophosphate [12,13].