AGER and inflammatory bowel disease: In contrast, information on key aspects of this important innate immune receptor remains sparse in the placenta and intestine, where an involvement of RAGE in the pathogenesis of pregnancy-associated diseases (PE, GDM, FGR) [39,41,43,[64], [65], [66]] and inflammatory bowel disease [[30], [31], [32],[67], [68], [69]] has been suspected but remains controversial.