(75) used dextran sulfate solution (DSS) to induce gut-leakage in FcGRIIb-/- mice and found that DSS-induced gut-leakage induced high anti-dsDNA immunoglobulin in serum, enhanced lupus features including proteinuria and serum creatinine, caused the gut translocation of molecular components of gut pathogens, enhanced MLN apoptosis and induced spleen apoptosis in FcGRIIb-/- mice. The gene discussed is FCGR2B; the disease is systemic lupus erythematosus.