Early postoperative plasma mtDNA level is associated with postoperative SIRS and multi-organ failure (93).The plasma mtDNA level of patients undergoing MiECC is lower than that during CPB surgery and is positively correlated with postoperative myocardial injury (94).MtDAMPs such as TFAM and cytochrome c elevated in venous grafts after CABG surgery (95). Here, CYCS is linked to systemic inflammatory response syndrome.