LCN2 and Sepsis: Kangelaris and colleagues (8) previously reported that RETN, TCN1, OLFM4, LCN2, BPI, and MMP8 neutrophil degranulation genes were upregulated in the peripheral blood of 28 older adults during sepsis-related ARDS (72% due to pneumonia/lung aspiration) compared to those with sepsis without lung involvement.