Liver cirrhosis can be caused by various toxic, metabolic, infectious, or autoimmune conditions such as alcoholism, non-alcoholic fatty liver disease (NAFLD), autoimmune hepatitis, viral hepatitis, primary biliary cholangitis (PBC), and primary sclerosing cholangitis, as well as a variety of metabolic disorders such as Wilson's disease, hemochromatosis and alpha-1-antitrypsin deficiency (1). This evidence concerns the gene SERPINA1 and primary biliary cholangitis.