HPV insertion/integration (OR = 2.302, CI = 1.523-3.589, <i>P</i> = 0.0005), <i>APOBEC</i> enrichment (OR = 17.875, CI = 2.117-150.937, <i>P</i> = 0.001), and <i>HLA-B*39</i> in <i>HLA-I</i> (OR = 6.435, CI = 0.823-48.919, <i>P</i> = 0.0042) were risk factors for cervical cancer, while <i>HLA-DQB1*05</i> in <i>HLA-II</i> was a protective factor (OR = 0.426, CI = 0.197-0.910, <i>P</i> = 0.032). The gene discussed is HLA-B; the disease is cervical cancer.