AD, atopic dermatitis; BL, baseline; CADD, Combined Annotation Dependent Depletion; EASI, Eczema Area and Severity Index; LoF, loss of function; pos.pathogenic, possibly pathogenic; STAT6, signal transducer and activator of transcription 6; TEWL, transepidermal water loss; TLR2, toll-like receptor 2. Here, STAT6 is linked to Alzheimer disease.