The relation of DOCK8 with AD has only been sparsely reported thus far, whereas DOCK8 deficiency due to recessive damaging variants is a well-documented cause of hyper IgE syndrome and a tendency to viral infections (Biggs et al., 2017; Boos et al., 2014; Jacob et al., 2019; Yamamura et al., 2017). Here, DOCK8 is linked to hyperinsulinemic hypoglycemia, familial, 4.