IGHE and Alzheimer disease: This included two patients with two such DOCK8 variants (NM_203447:c.A3535T p.S1179C/c.A4019G p.Y1340C and c.C305T p.T102I/c.C986T p.A329V), but it is not known whether these variants occurred in cis or trans. These two patients had parental AD, moderate disease, normal serum total IgE levels, slightly elevated eosinophil counts (0.40−0.53 E9/l), and positive aeroallergen sensitizations at baseline.