Differentiation of SARS-CoV-2-specific CD4+ T cells into Th1 and Tfh cells in response to SARS-CoV-2 has been observed, and SARS-CoV-2 specific circulating Tfh cells, which are responsible for the generation of virus-specific neutralizing antibody response, and memory B cells were found to be accelerated in the acute phase of COVID-19 (Rydyznski Moderbacher C et al., 2020; de Candia et al., 2021; Jarjour et al., 2021; Sette and Crotty, 2021). The gene discussed is CD4; the disease is COVID-19.