One study proposes that the use of HLA-E-restricted CD8+ T cells will give many benefits to patients having COVID-19 to improve T-cell immunotherapy, such as the combined ability to destroy infected cells and prevent intracellular infections by minimizing the level of the inflammatory response and reducing adjacent tissue damage, of what is being considered as an essential factor of the pathway (Caccamo et al., 2020; Vardhana and Wolchok, 2020). This evidence concerns the gene HLA-E and COVID-19.