Significant clusters were associated with the linked transcription factors and transcriptional factor enrichment analysis within these regulatory networks led to the proposition of Pou5f1b, Znf428, Prmt3, Znf12, Erg, Tfdp1, Foxm1, and Cenpa as new drug targets in drug development that can be applied in different cancer types. This evidence concerns the gene PRMT3 and cancer.