PTEN and breast carcinoma: Activated PPARγ can also bind to the PTEN promoter; this leads to the up-regulation of PTEN in both normal and cancerous cells such as macrophages, colorectal cancer cells, and breast cancer cells,65 For example, PTEN expression increases with rosiglitazone (PPARγ selective ligand to activate PPARγ); this decreases hepatocarcinoma cell line (BEL-7404) migration.66