Mechanistically, down-regulation of miR-320 up-regulates v-ets erythroblastosis virus E26 oncogene homolog 2 (ETS2) in PTEN-deleted mammary stromal fibroblasts which activates an oncogenic secretome that reprogrammes the tumor microenvironment and promotes angiogenesis and tumor cell invasion.126. This evidence concerns the gene PTEN and neoplasm.