Cluster Fib_5 prominently expressed MHC-II genes (HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB5, HLA-DRB1, HLA-DRA, HLA-DPA1, and HLA-DPB1), indicating their role as antigen-presenting cells with tumor-suppressing effects. The gene discussed is HLA-DPA1; the disease is neoplasm.