CTLA4 and neoplasm: Cytotoxic effector molecules (GZMB and GZMA) and pro-inflammatory cytokines (IL32 and CCL5) were highly expressed in a special class of CD8+ T cells (LAG3-, CTLA4-, CD96−, and HAVCR2-), indicating that the cells were immune-activated tumor-infiltrating lymphocytes (TILs) and their abundance is beneficial for suppressing aggressive neoplasias.