CPA3 and cancer: The identified cell lineages included proximal renal tubular cells (GPX3 and ALDOB), distal renal tubular cells (DEFB1, CKB, and EPCAM), collecting duct cells (KRT7, SLC26A4, and KRT18), cancer cells (NDUFA4L2 and NNMT), ECs (CLDN5, PECAM1, and KDR), myeloid cell (LST1, LYZ, and C1QB), smooth muscle cells (TAGLN and ACTA2), fibroblasts (COL1A1, COL3A1, PDGFRB, and DCN), T-cells (CD3D, CD3E, and NKG7); B cells (MS4A1 and CD79B), and mast cells (TPSB2 and CPA3) (Figures 1A–C).