IGFBP3 and neoplasm: Additionally, TIMP3, SPARC, IGFBP3, and IGFBP7 were highly expressed in the Mac_5 cluster, and these genes were involved in immunosuppression, tumor cell proliferation, and angiogenesis (Kielczewski et al., 2009; Pianta et al., 2015; Min et al., 2016; Talior-Volodarsky et al., 2017; Wang et al., 2021a; Rao et al., 2022).