FAS and neoplasm: Moreover, MALAT1 upregulated the expression of CD36 and liposynthases (PPARγ, PGC1α, SREBP-1C, FAS, and ACC), enhancing unsaturated fatty acid synthesis and uptake, thereby promoting tumor cell progression (Huangfu et al., 2018; Ebrahimi et al., 2020; Wang et al., 2021d).