Further, additional known risk factors are suggested to play a role in the interaction between CU and CT on the risk of PLE, such as the COMT gene [60, 61], white matter integrity [62], urbanicity [50, 55, 56], threat-induced cognitive biases [57], cognitive alteration [56], cognitive fusion [37], and affective comorbidity [55, 56], with SLEs being relevant for ROP [41]. Here, COMT is linked to retinopathy of prematurity.