Consequently, the expression of P2X3 and P2X4 is overtly increased in DRGs, as evidenced by high levels of P2X3 and incremental co-expression of P2X4 and GFAP in this finding, and their suppressions relieve mechanical hyperalgesia in neuropathic pain animal models [75-80]. Here, P2RX3 is linked to neuropathic pain.