Based on their surface marker expression, COVID-19-associated LDNs can be categorized into four distinct subsets: CD33++CD16-CD11b-, CD33+CD16-CD11b+, CD33lowCD16+CD11b+ and CD33-CD16+CD11b-/low, which represent different stages of maturation in the development of granulocytes, including promyelocytes, myelocytes, bands and mature granulocytes [43]. The gene discussed is CD33; the disease is COVID-19.