NADPH oxidase activity is crucial for control of staphylococcal infections as shown by the fact that mice lacking components of the NADPH oxidase complex, p47phox (Ncf1) or p91phox (Cybb or Nox2), are susceptible to spontaneous skin infections by S. xylosus [71–73]. Here, FMO5 is linked to staphylococcal infection.