ABCG8 and obesity due to melanocortin 4 receptor deficiency: Song et al.found that DMY alleviated obesity by up-regulating the genes related to BA conjugation (Bacs and Bat) and secretion (Bsep, Mrp2, Abcg5 and Abcg8), and down-regulating the genes related to bile acid re-absorption (Asbt, Ostα and Ostβ) of liver in obese ob/ob mice [21].