Few recent staging attempts based on pure neuropathological data have been performed for FTLD-TDP with behavioural variant frontotemporal dementia (bvFTD) or with amyotrophic lateral sclerosis (ALS) [11, 12], and for subvariants of FTLD-Tau [31, 38], yielding information on hypothesized sequential patterns of pathological involvement. The gene discussed is MAPT; the disease is amyotrophic lateral sclerosis.