In this EWAS examining DNAm and 28-year CVD risk in type 1 diabetes, we identified several CVD-associated CpGs in loci across the genome, including sites in GPM6A, CHRNA9, GAS7, GET4, MAD1L1, and MIB2. To our knowledge, this is the first report of a prospective EWAS of CVD in a type 1 diabetes cohort. Here, CHRNA9 is linked to type 1 diabetes mellitus.