Another study highlights the ability of BA to alleviate chronic hypoxia-induced PAH by enhancing adenosine A2A receptor activity and suppressing stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine receptor type 4 (CXCR4)-induced PI3K/Akt signaling [251]. This evidence concerns the gene CXCL12 and pulmonary arterial hypertension.