Regarding colon cell positivity for Granzyme-B, we found no positively stained cells in AAT-treated and non-treated control mice, whereas colon samples of AOM/DSS + AAT mice with cancer pT0 or pT1 stages were significantly more positive than samples of AOM/DSS mice (Figs. 7A and B). The gene discussed is SERPINA1; the disease is cancer.