GPER1 and schizophrenia: As the NLR and PLR correlate positively with the chlorpromazine equivalent dose of antipsychotics, it appears that female patients are more sensitive than males to the effects of these drugs, perhaps because some estrogen receptors (such as the G Protein-Coupled Estrogen Receptor 1) mediate anti-inflammatory effects and are under-expressed in individuals with schizophrenia [35].