The presence of both TDP-43 filaments and TMEM106B filaments in type A FTLD-TDP, as well as in ALS with type B FTLD-TDP9,22, is at odds with a recent report of amyloid filaments in FTLD-TDP being composed of TMEM106B but not TDP-43 (ref. 21). This evidence concerns the gene TMEM106B and amyotrophic lateral sclerosis.