TP53 and cancer: In the cancer-associated wikipathway result, there were five up-regulated pathways: photodynamic therapy-induced HIF-1 survival signaling, apoptosis, TP53 network, DNA damage response, and cytokines and inflammatory response; meanwhile, eight pathways were down-regulated including retinoblastoma gene in cancer, cell cycle, G1 to S cell cycle control, DNA IR-damage and cellular response via ATR, DNA mismatch repair, ATM signaling pathway, regulation of sister chromatid separation at the metaphase-anaphase transition, DNA IR-DBSs and cellular response via ATM (Fig. 5D).