Further, as shown in the split UMAP plot of the Dx T-ALL and healthy control samples (Fig. 1e), some of the cell clusters (NK, B, Erythroid, Monocyte/macrophage clusters) contained cells from both the control and T-ALL samples, while two of the CD3D +  clusters, 6 and 14, were enriched mostly in controls (Con T). This evidence concerns the gene CD3D and acute lymphoblastic leukemia.