Following our findings, many studies demonstrated the relation of different polymorphisms of this axis with cardiac diseases; Singh et al. study determined that thalassemia patients having RANK rs75404003 (C > DEL), OPG rs2073618 (G > C), and minor C allele of OPG rs2073618, were at high risk for developing left ventricular hypertrophy25. This evidence concerns the gene TNFRSF11B and thalassemia.