This study aimed to explore the relationship between genetic variants of the OPG/RANK/RANKL axis and iron-overload-induced cardiac abnormalities in children with TDT, as this axis was linked before to oxidative stress-induced disease7, and oxidative stress is the primary mechanism involved in thalassemia iron-overload-induced cardiomyopathy24. The gene discussed is TNFRSF11A; the disease is Tangier disease.