Increased amounts of relaxed Fibronectin have been previously reported in the cancer stroma in the proximity to myofibroblasts.39 Fibronectin regulates cell adhesion and motility, which determine the speed of wound healing, as well as the invasiveness of cancer cells.61,62 Our scRNAseq data show activation of molecular regulators of cell contractility and motility in carious dental pulps, but it is unclear whether they are a direct result of changes in the Fibronectin tension status and ECM remodelling. Here, FN1 is linked to cancer.