CD4 and neoplasm: Interestingly, although no statistical difference in the cell ratio of CD4+NR4A3 was observed between normal lung tissues (nLung, n = 11) and early (tLung, n = 11) or late/metastatic LUAD (tL/B, n = 4) (p > 0.05), we noticed its emergence in selected tumor tissues (tLung) and brain metastases (mBrain) compared to normal lung tissues and it exhibiting high heterogeneity (Fig. S6D, E), consistent with our study.