She carried a de novo likely pathogenic c.512 G > A, p.(G171D) [NM_001005463.3] variant in EBF3. The second was a six-year-old male with a cleft soft palate who carries a pathogenic de novo c.487 C > T, p.(R163W) [NM_001005463.3] variant in EBF3. He was born prematurely and had intrauterine growth restriction. This evidence concerns the gene EBF3 and fetal growth restriction.