The third was a 5-year-old female with a cleft palate who carries a de novo likely pathogenic c.661 G > A, p.(V221M) [NM_001005463.3] variant in EBF3. She was also noted to have delayed speech, intellectual disability, hypotonia, epicanthal folds, micrognathia, camptodactyly, and hyperextensibility. This evidence concerns the gene EBF3 and Intellectual disability.