For example, mandibulofacial dysostosis in Treacher Collins syndrome is linked to mutations in several ubiquitously expressed genes, including TCOF1 and components of RNA Polymerase I, POLR1C and POLR1D. While such genes are clearly important for normal craniofacial development, they likely exert their effects at the post-transcriptional and/or translational levels, making them difficult to interrogate with the data that we have collected. This evidence concerns the gene TCOF1 and mandibulofacial dysostosis.