RAD51 and neoplasm: Importantly, within this CESC data set, unlike data sets from most APOBEC-mutated tumor types, the overall number of copy number changes within tumors does not correlate with the number of base substitutions (Fig. 7C), ensuring that the associations we observed between somatic single-gene deletion in RAD51 and RAD51C are unlikely to result from tumors with higher copy number burden and thus are more likely to have deletions in RAD51 or RAD51C, having de facto higher mutation burdens.